| David Duchovny | Fox Mulder |
| Gillian Anderson | Dana Scully |
| Mitch Pileggi | Walter Skinner |
| William B. Davis | Cigarette Smoking Man |
| Nicholas Lea | Alex Krycek |
| John Neville | Well-Manicured Man |
| Stefan Arngrim | Prisoner |
| Jan Rubes | Vassily Peskow
(as Jan Rubés) |
| Fritz Weaver | Senator Albert Sorenson |
| Brent Stait | Timothy Mayhew |
| Malcolm Stewart | Dr. Sacks |
| Campbell Lane | Senator Romine |
| Robin Mossley | Dr. Kingsley Looker |
| Brenda McDonald | Auntie Janet |
| Pamela MacDonald | Nurse |
| Eileen Pedde | Angie |
| Jessica Schreier | Dr. Bonita Charne-Sayre |
| Tatiana Chekhova | Truck Driver's Wife
(uncredited) |
| Raoul Ganeev | Russian Guard
(uncredited) |
| Bathsheba Garnett | Woman
(uncredited) |
| John Hainsworth | Gaunt Man
(uncredited) |
| Denis Krasnogolov | One-Armed Leader
(uncredited) |
| Vitaly Kravchenko | Russian Truck Driver
(uncredited) |
| Igor Morozov | Russian Horseman
(uncredited) |
| Anatol Rezmeritza | Glasses Man
(uncredited) |
| Olesky Shostak | Bundled Man
(uncredited) |